Re: Zoladex-desperately need info

From: Christine M. Smith (
Wed Sep 1 18:44:55 1999

It is not At Wed, 1 Sep 1999, Ginny King wrote: >
>Hi Sharonda'
>I don't know anything about Zoladex. I did take Lupron injections for
>six months. I personally had a tough time with the side effects but
>others have had success. I suffered with migraine headaches for the
>first time while on the drug along with bone pain and severe hot
>flashes. Another lady on the forum mentioned that they now can do
>estrogen replacement therapy which I would think would minimize some of
>the side effects. I forgot to ask her, but one thing I wonder is if the
>estrogen replacement would in any way reduce the effectiveness of the
>Lupron since part of the reason it works on endo is by depriving the
>body of estrogen. I would think they would not prescibe it if it did
>not work. Anyway, sorry I'm not much help. I do feel that Lupron needs
>to be considered carefully before taking it. Maybe the Zoladex has
>fewer side effects? Take care. Ginny


I have mentioned "add back therapy" with estrogen in the past. The first time I had Lupron they weren't doing this and when I had the second, 3 month trial run, I did have add back therapy. My gyn said it does seem odd but the results were coming in favorably. They only give a very small amount of estrogen back, nothing like what your body normally makes. I think to understand this you would have to have a good understanding of reproductive biochemistry. It's beyond me. I had a very odd response to Lupron according to my gyn. Unless he was "bs-ing" me, and why would he do that, he said he had never seen a response to Lupron as he did in me. It is not supposed to affect adhesions, yet after 6 months on Lupron my entire pelvis was soft and normal feeling, not scarred feeling the way it was previously. I asked him why and he shrugged his shoulders. Then when I had my pain incident about 1 1/2 years after Lupron therapy I was once again scarred feeling. Very strange.

Chris S.

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