The last part of this Url is: ( Koontz.htm ) ( http://www.burtonreport.com/InfSpine/AdhesArachEpiInjKoontz.htm )
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" Since the withdrawal of oil-based myelography Depo-Medrol and Depo-Medrone have become the principal cause of clinically significant adhesive arachnoiditis in the Western world. Depo-Medrol (and other similar suspensions) are being administered epidurally as routine off-label and ill-advised, treatments for back pain. The rationale given for the use of these suspensions is that their main ingredient, methylprednisolone, is an anti-inflammatory agent.
" Although basically true in concept, suspensions of synthetic glucocorticoids are effective anti-inflammatory agents; but they also contain preservatives such as polyethylene glycol, known better as a anti-freeze in car cooling systems. Other preservatives include alcohol. Both ethylene glycol and alcohol are well-recognized toxic agents if introduced into the sub-arachnoid space.
" As with any "off-label" use of a drug or device their application is dependent upon the individual doctor’s discretion and clinical judgment. It is the individual physician who then takes personal responsibility for this.
" In both the U.S. and England epidural steroid injection (ESI) in the treatment of back pain is practiced extensively and by a variety of clinicians including general practitioners, anesthesiologists, radiologists and specially trained physiotherapists."
WARNING: IF YOU ARE CONSIDERING EPIDURAL INJECTIONS INTO YOUR LUMBAR SPINE, YOU MUST READ THE REST OF THIS ARTICLE --- FOR YOUR OWN SAFELY!!