http://www.med.virginia.edu/medicine/basic-sci/biomed/ley/firm_adhesion.htm
At Fri, 19 May 2000, Bernie and Beverly Doucette wrote:
Hello Joyce, I have said all along that every ARD sufferer should have a WBC ( White Blood Count ) to see if in fact it is elevated. Mine was elevated all the time, and what a puzzle for the " ordinary " DR. who had no knowledge of the symptoms or reality of adhesion disease! I also feel that pain medication without at least 1300 mgs of an anti-inflammatory medication is ineffective in fighting the symptoms of adhesion disease. As for studies on anything that has to do with adhesions, there are in fact some very good studies currently underway to study the intercellular biochemical etiology of adhesion formation. It is hoped that one day, adhesions can be effectively treated by the use of medication, such as in diabetes. If we, lay people, can figure some of this out, one would think a few Dr's could wouldn't you?? !! :-)
Just a few web sites that I research as far as bio-chemistry and intercellular structures regarding adhesion formation,etc...lots of research IS being done, but nothing conclusive at this time as far as how to abort the process intra - abdominally!
http://www.med.virginia.edu/medicine/basic-sci/biomed/ley/firm_adhesion.htm
http://www.grc.uri.edu/programs/1999/cellcont.htm
http://www.burnham-inst.org/whats.new.html
Joyce, I found this to be interesting!!
3. Regulation of avidity modulation of integrin Tatsuo Kinashi, Tetsuo Asaoka, Ruri Wada, Shinichi Watanabe and Kiyoshi Takatsu
Adhesion of cell-cell and cell-matrix mediated by integrin plays crucial roles in leukocyte migration to inflamed tissues, and also in cell migration during embryogenesis. Adhesion mediated by integrin is known to be regulated by modulations of cell surface expressions and avidity of integrin. In fact, mere expressions of integrin does not necessarily lead to ligand binding. For example, T cells have VLA-4 and LFA-1 on the cell surface, but adhere to fibronectin and ICAM-1, respectively, only when stimulated with cross-linking of the T cell receptor or phorbol ester, PMA. Avidity modulation of integrin is particularly important for regulation of adhesion of hematopoietic cells and lymphocytes.
More reading on same in this web page:
http://www.ims.u-tokyo.ac.jp/meneki/research/96/res.96-3.html
Bev
>----- Original Message -----
From: Joyce <Joyce@bellsouth.net>
To: Multiple recipients of list ADHESIONS <adhesions@forum.obgyn.net>
Sent: Friday, May 19, 2000 7:26 AM
Subject: Re: CBC Lymph count
Being that I'm fairly new to this forum, and I find great comfort from hearing everyone else's stories (we are all together in this it seems), I've spent some time this morning reading over prior months' messages. I had to take note that it seems a lot of people with adhsions that are in pain, including myself, also have problems keeping themselves up mentally. Not that pain alone cannot do that(I know it can), and I can't speak for everyone, (I feel I'm still in the early stages of all of this with only 2 surgeries and no complete bowel obstruction as of yet) but this posting from Tina caught my attention. Lymphocytes are part of the white blood cell type. They travel to areas of inflammation and will be increased with diseases such as mono, viral infections, must viral upper respiratory infections, mumps, rebella,rubeola, hepatitis and some bacterial infections such as tuberculosis, and syphilis. In our situation, knowing that adhesions can be causing inflammation, I have to wonder if the lymp count is elevated in response to that. I see another potentially great research question/project. I remember reading in a medical book that a rise in White Blood cell count to fight viral infections (or in this case, inflammation) has been suspected to be a possible cause of short-term depression. Maybe I'm just grasping at straws here and overanalyzing(which I've been known to do from time to time... LOL) but I know that for me, sometimes dealing with the pain is worse than the actual pain. I mean the pain is bad, but I just don't have the strength to deal with it sometimes. I used to have lots of ear infections (bacterial infection), my Mom didn't always have the money to send me to the doctor so I would be in serious pain a lot.... a whole lot. I handled that pain better than I handle this adhesion pain, and believe me, if you've ever had an eardrum to rupture, you know, that's one of the worst pains you can feel. I was lots younger causing me to have such a hard time dealing with this pain.... Not really sure where I'm going with this, I guess just thinking outloud for the most-part, but I thought it was interesting and just wanted to share. But I do think the next time I see my PCP on one of my really bad days, I'll see if he'll do a blood cell count...I hope everyone is doing ok today and thanks for all of your stories...I believe this forum has been the best medicine yet for me.... Thanks Guys!!!!!
-- JoyceAt Tue, 15 Feb 2000, Jaynie Jarvis wrote:
At Mon, 14 Feb 2000, Tina Shelby wrote:
Sorry to have taken so long to write back. I've been away from my computer so I am trying to get caught up. I wanted to discuss the purpose of lymphocytes in our bodies and what can cause them to be elevated.
Lymphocytes are part of the white blood cell type. They travel to areas of inflammation and will be increased with diseases such as mono, viral infections, most viral upper respiratory infections, mumps, rebella, rubeola, hepatitis and some bacterial infections such as tuberculosis, and syphilis.
In our situation, knowing that adhesions can be causing inflammation, I have to wonder if the lymph count is elevated in response to that. I see another potentially great research question/project.
Tina,
Sure they come to the site of inflammation, it is part of the healing process. I can't remember where I read this or who told me. They said, "Think of what happens to a sliver in your hand "First it gets pussy and then, when the body can't get rid of it, it incapsulates it in a fibrous material. Scar tissue. And it keeps building it to protect the body from foreign objects. Same thing happens in side us and over time it connects itself and grows tougher. Foreign objects could just be blood left inside us. BUMMER !!! JAYNIE
--Joyce